A novel approach of administering platelet-rich plasma and gonadotropins near the ovarian follicles is showing promise in restoring ovarian function in women with early menopause.
As more women look to build their careers before pursuing motherhood, the average age of conceiving a child continues to be pushed back.
For some of these women, however, their hope of becoming pregnant is cut short by the onset of early menopause, which is described as the cessation of ovarian function at or before the age of 45 years.
It is estimated that roughly 12.2% of women experience early menopause.
Menopause typically signals the end of a woman’s ability to become pregnant. For these women, the only chance of becoming pregnant is with donor eggs.
Multiple treatment options have previously been investigated, including standard, controlled ovarian stimulation.
Platelet-rich plasma has been used in women with primary ovarian insufficiency, but few pregnancies and live births resulted. With the failure of these somewhat traditional treatments, more novel approaches, such as methods for inducing the growth of ovarian follicles, are being pursued.
In this new, small-scale pilot study, platelet-rich plasma and gonadotropins were injected into the ovaries of study participants, with some fairly amazing results.
After treatment, 11 of the 12 study participants resumed menstruation, and one achieved clinical pregnancy, defined as a pregnancy that is confirmed by ultrasound as well as a fetal heartbeat.
Platelet-rich plasma, prepared from 40 mL of autologous peripheral blood using the buffy coat method, was injected into extended subcortical area of bilateral ovaries along with recombinant follicle-stimulating hormone (rFSH) (Gonal-F 300IU) under laparoscopic guidance. The posttreatment ovarian folliculogenesis and serum levels of FSH, luteinizing hormone (LH), and estradiol were followed up for 6 months at weekly to monthly intervals. IVF was carried out in women resuming ovulatory functions.
Although more research and larger studies are needed, these early results regarding the successful resumption of ovarian function offer hope to women in early menopause who may be able to pursue pregnancy through in vitro fertilization using their own eggs.
“This pilot study investigating the use of platelet-rich plasma and gonadotropins injected into the ovaries of women with early menopause highlights the promise of regenerative medicine in restoring or prolonging fertility. Additional studies conducted prospectively and involving large numbers of women are needed to determine whether this is truly a viable option for women with early menopause hoping to achieve pregnancy using their own eggs,” says Dr. Stephanie Faubion, NAMS medical director.
Results are published in the article “Resumed ovarian function and pregnancy in early menopausal women by whole dimension subcortical ovarian administration of platelet-rich plasma and gonadotropins.”