FERTILITY

COVID-19 leads to more women freezing their eggs

COVID-19 leads to more women freezing their eggs

Fertility clinics have seen a sharp rise in the number of women inquiring about egg freezing – up to 50 percent more inquiries at some clinics.

They have reported that for many of these women, the lockdown has triggered a period of reflection over their parental future, particularly given that opportunities to meet a partner have been greatly reduced.

Kate Davidson from Cheltenham, who is 35 and single, told the Sunday Times: ‘A big part of me wanted to do it because I wanted to share my eggs… But I also like the fact that I’ve got some put away for me now. I was quite reflective about work, life – all those things. I think that’s what prompted me to make the move.’

‘The whole way in which we socialise and date has changed… if I don’t meet the man of my dreams until I’m 39, then at least I know I’ve got the eggs of a 33-year-old’ said a woman named only as Katherine, in the same article. ‘I just haven’t met that person, and with the coronavirus, I felt that it was becoming harder. That was the trigger.’

Compared with last summer, both Create Fertility and The London Women’s Clinic have seen consultations for egg freezing rise by 25 percent, while the King’s Fertility and Harley Street Fertility Clinics reported rises of 15 and 20 percent respectively.

‘Social’ egg freezing refers to patients who choose to preserve their fertility for lifestyle rather than medical reasons and is only available privately.

A recent report by the Human Fertilisation and Embryology Authority showed that the number of women opting to freeze their eggs or embryos in the UK rose 523 percent between 2013 and 2018.

Professor Joyce Harper, professor of reproductive science at University College London, said: ‘The majority of women who freeze their eggs… are single. When they’ve been asked, most of them want to have children now, they just haven’t met Mr Right or haven’t got a partner who is happy to have children.’

Currently, UK law prevents eggs frozen for non-medical reasons to remain in storage for more than ten years. A recent report from the Nuffield Council on Bioethics joined other voices in the field in calling for this limit to be removed.

Sarah Norcross, director of the Progress Educational Trust, said ‘With more women than ever choosing to freeze their eggs, it is time for the law to be changed’.

Source: https://www.bionews.org.uk/page_152631

COVID-19 could cause male infertility

COVID-19 could cause male infertility

Males who suffer from moderate or severe cases of COVID-19 could experience reduced fertility, according to a new study conducted by Dr. Dan Aderka of Sheba Medical Center.

Aderka reported that not only was the virus found within the sperm of some 13% of screened male COVID-19 patients, but that there was a 50% decrease in the sperm volume, concentration and motility in patients with moderate disease even 30 days post diagnosis.

Post-mortem tests of 12 COVID-19 patients demonstrated moderate to severe changes in the testicular cells supporting sperm development and those producing testosterone, the hormone that induces sperm division and multiplication.

Aderka, whose article was published in the medical journal Fertility and Sterility, told The Jerusalem Post that the cause for this phenomenon seems to be the presence of the ACE2 receptor on the surface the cell of the Sertoli and Leydig cells of the testis, the same receptors on the cells of lungs, kidneys and hearts.

The Sertoli cells support sperm maturation. The Leydig cells produce testosterone.

He said the coronavirus binds to the ACE2 receptors and destroys the cells, which causes infertility.

As normal sperm maturation takes 70 to 75 days, it is possible that if we are doing a sperm examination two and a half months after recovery, we may see even more reduced fertility,” Aderka said. “It could be even more detrimental.”

He added that it is also still unclear if the effects on the quality and quantity of the sperm are reversible or persistent. He said doctors will need to examine these same patients six months and a year after recovery to see if the damage “stands the test of time.” This is something his team is planning to do.

Aderka said that there is another hypothesis that can now be explored, also as a result of his research: “Interestingly, an enzyme called TMPRSS2 assists the virus in binding to the ACE receptor, facilitating its internalization into the cells.”

TMPRSS2 is activated by testosterone.

This phenomenon may explain the higher COVID-19 morbidity and mortality of men compared to women,” he told the Post, adding that it also may explain the lower morbidity and mortality of children, whose testosterone levels are low.

Source: https://www.jpost.com/health-science/covid-19-could-cause-infertility-new-israeli-study-644767

Light from devices at night affects sperm quality

Light from devices at night affects sperm quality

Men might want to think twice before reaching for their smartphone at night. A new study found correlations between electronic media use at night and poor sperm quality.

Preliminary results show that greater self-reported exposure to light-emitting media devices in the evening and after bedtime is associated with a decline in sperm quality.

Sperm concentration, motility and progressive motility — the ability of sperm to “swim” properly — were all lower, and the percentage of immotile sperm that are unable to swim was higher, in men who reported more smartphone and tablet usage at night.

Smartphone and tablet use in the evening and after bedtime was correlated with decline in sperm quality. Furthermore, smartphone use in the evening, tablet use after bedtime, and television use in the evening were all correlated with the decline of sperm concentration,” said principal investigator Amit Green, PhD, head of research and development at the Sleep and Fatigue Institute at the Assuta Medical Center in Tel-Aviv, Israel.

“To the best of our knowledge, this is the first study to report these types of correlations between sperm quality and exposure time to short-wavelength light emitted from digital media, especially smartphones and tablets, in the evening and after bedtime.”

The researchers obtained semen samples from 116 men between the ages of 21 and 59 years who were undergoing fertility evaluation. Participants completed questionnaires about their sleep habits and use of electronic devices.

The study also found a correlation between longer sleep duration and higher sperm total and greater progressive motility. In contrast, greater sleepiness was associated with poorer sperm quality.

The research abstract was published recently in an online supplement of the journal Sleep for Virtual SLEEP 2020. SLEEP is the annual meeting of the Associated Professional Sleep Societies, a joint venture of the American Academy of Sleep Medicine and the Sleep Research Society.

Read more: https://academic.oup.com/sleep/article-abstract/43/Supplement_1/A12/5847498?redirectedFrom=fulltext

New male fertility test offers clarity for couples struggling to conceive

New male fertility test offers clarity for couples struggling to conceive

Infertility affects 10% to 15% of couples globally, and while often viewed as a women’s health problem, men contribute to around half of the cases.

A new male fertility test based on Cornell research could help predict which men might need treatment and which couples might have success with different forms of assisted reproduction.

“The ‘Cap-Score test is designed to provide information on the man’s fertility that they never had before,” said Dr. Alexander Travis, professor of reproductive biology at the Baker Institute for Animal Health and the test’s inventor.

“Now, doctors can discuss these results with the couple, and help them choose the personalized treatment pathway that is right for them to try to get pregnant, including how to improve the man’s fertility.”

The research was published in Reproductive BioMedicine Online. Travis is senior author.

The Cap-Score is a diagnostic test approved for use by medical doctors in all 50 states; the technology has been licensed to Androvia LifeSciences, LLC, a fertility research company co-founded by Travis, its chief science officer, in 2015. Travis holds equity in the company.

Cap-Score quantifies the ability of sperm to undergo a process called “capacitation,” which enables the sperm to fertilize an egg. Only sperm that capacitate are capable of fertilizing. By contrast, traditional male fertility exams rely primarily on semen analysis, which counts sperm and assesses whether they swim and look normal.

“Fertility exists in degrees; as long as a man produces some sperm that swim, he has some level of fertility,” Travis said. “But it is the functional ability of those sperm to fertilize an egg that influences the odds that a couple will become pregnant.”

The new research included prospective clinical pregnancy outcomes data from six fertility clinics. Prospective tests are important when evaluating a new diagnostic procedure because they show the ability to predict what will happen for patients.

Travis said Cap-Score‘s predictive ability “held true across different age ranges for the female partner.” This is important because there are many well-known impacts of maternal age on a couple’s fertility. The new data shows that the man’s fertility plays a key role in whether a couple will be able to conceive, even if they might have delayed having children and are older.

The researchers also compared Cap-Score results from more than 2,000 men having fertility exams at 22 clinics against results from a control group of fertile men with a pregnant partner or young baby. Cap-Scores from the fertile men showed an expected bell-shaped curve. In contrast, the vast majority of men questioning their fertility had scores below the mean of the fertile population.

Additionally, the researchers examined the relationship between traditional semen analysis results and impaired capacitation. “Men are often assumed to be fertile if they have enough normal-looking sperm that swim,” Travis said, “but we found that almost two-thirds of the men who had low Cap-Scores passed the traditional semen analysis.”

Infertility and most male infertility cases remain unexplained due to a lack of diagnostic testing. Not only does this place the onus of expensive and often invasive testing on women, it also may prompt couples to try expensive procedures that might be inappropriate for their situation. The Cap-Score can now provide crucial missing information to help guide their choices.

“Couples and doctors have had to make important decisions about their fertility without all the information they needed. This has caused a lot of anxiety and pain — physically, financially and emotionally,” Travis said.

Using the Cap-Score, doctors and couples can make informed decisions about whether to try to conceive unassisted or choose one of several medical approaches. The results can also be used to identify which men might benefit from treatment to improve their fertility, including changes in lifestyle, nutritional supplements or surgery.

Read more: https://www.rbmojournal.com/article/S1472-6483(20)30162-0/pdf

Human eggs use chemical attraction to ‘choose’ sperm

Human eggs use chemical attraction to ‘choose’ sperm

The fluid that surrounds an egg when it is released from the ovary acts as a chemical attractant to sperm, but may also select sperm from certain males over others.

Researchers from the universities of Manchester and Stockholm showed that follicular fluid contains chemical signals that improve the chances of successful fertilisation in humans.

‘Human eggs release chemicals called chemoattractants that attract sperm to unfertilised eggs. We wanted to know if eggs use these chemical signals to pick which sperm they attract,’ said lead author Dr John Fitzpatrick from Stockholm University.

The team used samples of sperm and follicular fluid from 16 couples undergoing assisted reproductive treatment. Sperm were able to swim towards either of two follicular fluids in a dish, or one follicular fluid and a control substance. Sperm swim through follicular fluid on their way to reach an unfertilised egg.

The researchers found that each woman’s follicular fluid attracted more sperm from some men than others. There was no obvious pattern to explain which man’s sperm would be attracted to a woman’s follicular fluid; it appeared to be random and didn’t necessarily correlate with a woman’s chosen partner.

It was a real surprise,” says Fitzpatrick. “This is the first time this has been described in humans It is possible that eggs are more attracted to genetically compatible sperm, which may increase the chance that they are fertilised”.

The researchers measured the number of sperm that were able to move into each follicular fluid sample. They found that the average difference in sperm count between the fluid that attracted the most and the least sperm was approximately 18 per cent.

Eggs attracting around 18 per cent more sperm from specific males would likely be pretty important during fertilisations inside the female reproductive tract”, since only a small fraction of sperm reach the egg after sex, says Fitzpatrick.

The chemical interactions between eggs and sperm after sex may also play a role in why some people have difficulty conceiving. In around one in three couples who have fertility problems, there is no clear cause, says Fitzpatrick.

‘The idea that eggs are choosing sperm is really novel in human fertility,‘ said senior author Professor Daniel Brison, from the Department of Reproductive Medicine at Saint Marys’ Hospital, Manchester. ‘Research on the way eggs and sperm interact will advance fertility treatments and may eventually help us understand some of the currently ‘unexplained’ causes of infertility in couples.’

Future studies need to explore whether the same interactions are also present in regular mammalian (particularly human) reproductive cycles, away from the context of assisted reproductive treatment.

The research was published in the Proceedings of the Royal Society.

Read more: https://royalsocietypublishing.org/doi/10.1098/rspb.2020.0805

HPV vaccination does not negatively impact fertility

HPV vaccination does not negatively impact fertility

Human papillomavirus (HPV) vaccine is used to prevent sexually transmitted HPV infections and cervical cancers. People who are not vaccinated and contract HPV may experience future fertility problems associated with the infection.

The vaccine currently approved by the FDA has been extensively tested and demonstrated to be both safe and effective with limited side effects.

However, a recent research study has reignited historical public concern regarding HPV vaccination and the risk of primary ovarian insufficiency and infertility in women.

There are more than 100 HPV types that are transmitted sexually or via any skin-to-skin contact in the genital area. Low-risk HPVs mainly cause wart formation on the genitals, anus, mouth, and throat, whereas high-risk HPVs, especially HPV 16 and HPV 18, are associated with HPV-related cancers.

These viruses mainly affect the squamous cells that form the inner surface of various genital organs, causing a variety of HPV-related cancers, such as cervical cancer, anal cancer, penile cancer, vaginal cancer, and vulvar cancer.

How effective is HPV vaccination?

There is one HPV vaccine, Gardasil 9, which is currently approved for use in the United States and licenced in 2014. Previously an earlier version of Gardasil was licenced and another vaccine called Cervarix. Presently, FDA-approved HPV vaccination provides protection against infections caused by 2 low-risk and 7 high-risk HPVs. The vaccine consists of 2 shots that are given 6 to 12 months apart.

HPV-EMVOLIASMOS-VACCINE-EMBOLIASMOS

According to the Centres for Disease Control and Prevention, HPV vaccine should be given to both boys and girls at the age of 11 or 12 years; however, the vaccine can also be given at the age of 9 years. The vaccine is most effective if it is given to someone before they become sexually active, whereas the vaccine may not be effective if given after getting the infection.

Does HPV vaccination cause infertility?

After the initial approval of the HPV vaccine in 2006 by the FDA, there was public concern regarding the safety of the vaccine with a particular focus on whether it could cause primary ovarian insufficiency or premature menopause.

To add to this concern, in 2014 a medical case report from Australia was published reporting three cases of unexplained premature ovarian failure in adolescent girls where an adverse reaction to Gardasil (HPV4) vaccination was hypothesized as a possible explanation.

The author of a recent study analyzing the National Health and Nutrition Examination Survey data on 8 million American women reported a correlation between women who had not had the vaccine and pregnancy.

At least 60% of women who did not receive HPV vaccine becoming pregnant at least once during the survey period (2007 – 2014), whereas only 35% of women who received the vaccine became pregnant.

While the authors concluded that in an age group of 25 – 29 years, HPV vaccinated women are less likely to become pregnant than women who are not vaccinated they have been roundly criticized for not taking into account the vaccine coverage in the respective age groups during the study period.

Critics of the research have also pointed out that if the vaccine does affect fertility then a similar correlation would have been observed in other countries with good HPV vaccine coverage like Australia and the United Kingdom.

According to the data collected by the Vaccine Adverse Event Reporting System database, there were three reports of primary ovarian insufficiency out of 29 million doses of the Gardasil 9 HPV vaccine distributed in the United States between December 2014 and December 2017.

All three were determined to be hearsay reports, meaning there was not enough information to confirm a medical diagnosis of primary ovarian insufficiency.

The authors of a recent study looking at 200,000 young women who received various adolescent vaccines including HPV vaccine found no correlation between HPV vaccination and increased risk of primary ovarian insufficiency.

The researchers calculated that among 58,871 young women who received the HPV vaccine, only one woman showed the symptoms of primary ovarian insufficiency, suggesting that HPV vaccine is unlikely to affect fertility in young women.

 

HPV-VACCINATIO-EMBOLIO

Particularly in men, HPV negatively affects various sperm parameters, including motility. The virus can also increase trophoblastic cell death and decrease the implantation of trophoblastic cells in the uterus.

These factors can potentially increase the risk of miscarriage, premature membrane rupture, or spontaneous premature delivery.

In women undergoing intrauterine insemination, infection with HPV is associated with a lower pregnancy rate. In these circumstances, it can be considered that a vaccine designed to prevent HPV infection should improve someone’s chances of having a successful pregnancy.

A 2017 study, published in the journal Paediatric and Perinatal Epidemiology, showed little overall association between HPV vaccination and the chances of conceiving for men and women — except among women with a history of sexually transmitted infections (STIs).

STIs are associated with lower fertility, but vaccinated women with an STI history had about the same chance of becoming as unvaccinated women who had never had an STI.

The study found no adverse effects of HPV vaccination on fertility and indicated that it may, in fact, protect fertility among individuals who have had other STIs. Our study should reassure those who are hesitant to vaccinate due to fertility concerns.” Kathryn McInerney, BUSPH Doctoral Student & Lead Author of the study

Researchers at Karolinska Institute in Sweden and their Danish colleagues monitored HPV-vaccinated girls via patient data registries in order to examine the incidence of a wide range of diseases and thus determine if there were any serious adverse effects of the vaccine.

Their results showed no significant increase in the examined diseases in the vaccinated girls relative to their unvaccinated peers. The 2103 study, published in the BMJ, included almost a million Swedish and Danish girls born between 1988 and 2000 and compared roughly 300,000 girls who had been HPV vaccinated with 700,000 who had not.

You could see our study as part of a societal alarm system, and as such it did not alert us to any signs that HPV vaccination carries a risk of serious adverse events” said Dr Lisen Arnheim-Dahlström, Associate Professor, Karolinska Institute.

There is currently no reliable evidence that links current or previous HPV vaccines with fertility-related problems. However, given the questions raised by the case reports and recent academic controversy around the way large systematic reviews of HPV vaccine safety are conducted, it is clear that further research is needed to conclusively establish whether there are any grounds to associate HPV vaccination with any reduction in male or female fertility.

It is important to remember that a lot of studies on vaccine outcome reported that HPV vaccine is both safe and highly effective in preventing cancer-causing infections.

With more than 12 years of HPV vaccine safety monitoring and research from the United States and other countries, we have robust data showing the HPV vaccines are safe.

With regard to concerns about HPV vaccination and fertility in women, CDC and FDA have not found any convincing evidence that HPV vaccines cause primary ovarian insufficiency (POI).

Also known as “premature menopause,” POI is a condition in which a woman’s ovaries stop functioning before age 40. Causes of POI include genetics, chemicals in the environment, cancer treatments, smoking cigarettes, autoimmune disorders, and some viral infections.

A 2018 study from CDC’s Vaccine Safety Datalink that included nearly 200,000 women did not find an increased risk of POI following HPV vaccination.

 

 

Source: https://www.news-medical.net/health/HPV-Vaccination-and-Fertility.aspx

Hungary to provide free IVF to boost population

Hungary to provide free IVF to boost population

Hungary will provide free in-vitro fertilisation (IVF) treatment to couples at state-run clinics, Prime Minister Viktor Orban has announced.

He said fertility was of “strategic importance”. Last month his government took over Hungary’s fertility clinics.

Mr Orban, a right-wing nationalist, has long advocated a “procreation over immigration” approach to deal with demographic decline.

The country’s population has been falling steadily for four decades.

Mr Orban described details of his fertility policy on Thursday, after bringing six fertility clinics under state control in December.

Free IVF treatment will be offered from 1 February, but it is not clear who exactly will be entitled to it.

Mr Orban also said the government was considering an income tax exemption for women who have three children or more. Starting this month, those with at least four children have been exempt.

“If we want Hungarian children instead of immigrants, and if the Hungarian economy can generate the necessary funding, then the only solution is to spend as much of the funds as possible on supporting families and raising children,” the prime minister said.

Mr Orban – who has been prime minister since 2010 – has based his campaigns on opposition to immigration.

In September last year, he told an international summit on demography that while other European leaders believed immigration was the solution to falling population numbers, he rejected this.

The prime minister then echoed the far-right “great replacement” theory, which claims that white European populations are being gradually replaced by people of non-European descent.

“If Europe is not going to be populated by Europeans in the future, and we take this as given, then we are speaking about an exchange of populations, to replace the population of Europeans with others,” Mr Orban told the conference at the time.

“There are political forces in Europe who want a replacement of population for ideological or other reasons.”

With an estimated birth rate of 1.48 per woman, Hungary is just one of many Eastern European countries facing demographic decline – due to both low birth rates and the emigration of working-age people to other EU nations.

Some of these countries have implemented their own policies to encourage birth rates to increase. Poland, for example, pays parents 500 zloty (£100) a month per child.

Croatia, which assumed presidency of the EU last week, said last year that population growth in the EU would be “a ­key question” for them.

“Demography needs to be put in the focus of EU policies in order to preserve the development of all member states,” Croatian minister Vesna Bedekovic told a European Economic and Social Committee conference in November.

“The birth rate currently stands at 1.59 on average… This is why Croatia has recognised demographic revitalisation as a key question for its further development.”

Source: https://www.bbc.com/news/world-europe-51061499

Male fertility got no boost from zinc, folic acid in study

Male fertility got no boost from zinc, folic acid in study

A rigorous U.S. government-led study found that zinc and folic acid supplements don’t boost men’s fertility, despite claims that they do.

The mineral and the vitamin are important for sperm production and are found in many common foods. Previous studies on whether over-the-counter supplements might boost sperm health have had conflicting results.

There were a few small trials that showed a benefit, but we needed some definitive evidence that this would work,” said lead author Enrique Schisterman, a researcher at the National Institute of Child Health and Human Development. The study published in the Journal of the American Medical Association showed it didn’t.

Schisterman called the results disappointing. Supplements cost about $60 a month compared with tens of thousands of dollars many couples spend on invasive medical treatment for infertility.

People who go through fertility treatment are really, really desperate to find something that works,” he said.

The institute paid for the study, which involved almost 2,400 men planning fertility treatments with their partners at four U.S. clinics.

The researchers avoided using over-the-counter supplements, which aren’t strictly regulated and may contain ingredients other than those listed on the label. Instead they created tablets that combined 5 milligrams of folic acid, similar to previous studies, and 30 mgs of zinc, a lower dose than in some studies to avoid potential side effects.

Half the men studied swallowed one tablet daily for six months; the other men took dummy pills. Several semen tests were performed during the study.

Over 18 months of follow-up, 820 babies were born, about equal numbers in each group. Sperm quality also was similar in both groups.

Sperm DNA changes linked with infertility were slightly more common in the supplement users and those men had more digestive side effects, which have been linked previously with zinc pills.

Infertility affects at least 50 million couples worldwide. It’s usually defined as not being able to conceive after a year of trying. Male infertility including low sperm counts or poor-quality sperm contributes to about 1 in 3 cases. Research suggests sperm counts in western countries have been declining for decades, for unknown reasons.

Read more: https://jamanetwork.com/journals/jama/fullarticle/2758450?guestAccessKey=47179784-451b-4342-aadd-5f74ea3f79b1&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010720

OB-GYNs hesitate to talk about fertility

OB-GYNs hesitate to talk about fertility

Many OB-GYNs are uncomfortable counseling their patients on fertility at a time when more women are delaying pregnancy and needing their doctors to be more vigilant about this education, according to a new study.

“We found that most OB-GYNs don’t bring up fertility with every patient, often because they believe the patient would bring it up if she wanted to discuss it,” said Rashmi Kudesia, M.D., reproductive endocrinology and infertility specialist at Houston Methodist and CCRM Houston and lead author on the study, published in the Journal of Reproductive Medicine. “It’s a missed opportunity when OB-GYNs don’t start the conversation because many women are routinely exposed to conflicting information about fertility, leading many to believe that they’ll have no issues conceiving and delivering.”

In fact, 82% of OB-GYNs surveyed believe women receive mixed messages about their optimal fertility window, and 68% said women seem to believe they can indefinitely postpone making childbearing plans.

“It isn’t unusual for women to believe that assisted reproductive technologies like IVF are their safety net because they hear so many success stories,” Kudesia said. “The reality is that IVF only has a 5% success rate for women in their mid-40s.”

Kudesia and her co-authors found that OB-GYNs were more likely to provide fertility counseling to married women between the ages of 27-40. For all age groups, single and lesbian women were less likely to receive fertility counseling than married women. It was also found that the 117 physicians who participated provided more counseling on contraception than fertility in nearly all age and relationship status groups.

“The results tell me that regardless of current relationship status or future plans for pregnancy, women need to bring up fertility at their next well-woman exam or ask for a referral to a fertility specialist,” Kudesia said. “Women who want to wait several years and even those who think they don’t want kids at all should still talk to their doctor about fertility so that they can make an informed decision about what is best for them.”

Source: https://www.houstonmethodist.org/newsroom/research-shows-ob-gyns-hesitate-to-talk-about-fertility/

Read more: http://www.reproductivemedicine.com/toc/auto_abstract.php?id=24782

Vaping may harm fertility in young women

Vaping may harm fertility in young women

E-cigarette usage may impair fertility and pregnancy outcomes, according to a mouse study published in the Journal of the Endocrine Society.

Many young and pregnant women are using e-cigarettes as a safer alternative to smoking, but little is known about the effects on fertility and pregnancy outcomes.

E-cigarettes are driving increases in tobacco product use among youth. According to the Centers for Disease Control and Prevention, the number of middle and high school students using e-cigarettes rose from 2.1 million in 2017 to 3.6 million in 2018 — a difference of about 1.5 million youth.

“We found that e-cigarette usage prior to conception significantly delayed implantation of a fertilized embryo to the uterus, thus delaying and reducing fertility (in mice),” said the study’s corresponding author, Kathleen Caron, Ph.D., of University of North Carolina at Chapel Hill, N.C. “We also discovered that e-cigarette usage throughout pregnancy changed the long-term health and metabolism of female offspring — imparting lifelong, second-generation effects on the growing fetus.”

In this study, researchers used a mouse model to examine whether e-cigarette exposure impairs fertility and offspring health. After exposure to e-cigarette vapor, female mice showed decreased embryo implantation and a significant delay in the onset of pregnancy with the first litter. Female offspring exposed to e-cigarettes in utero also failed to gain as much weight as control mice by the 8.5-month mark.

“These findings are important because they change our views on the perceived safety of e-cigarettes as alternatives to traditional cigarettes before and during pregnancy,” Caron said.

Read more: https://academic.oup.com/jes/advance-article/doi/10.1210/js.2019-00216/5560172

Source: https://www.endocrine.org/news-room/2019/vaping-may-harm-fertility-in-young-women

Visit Us On FacebookVisit Us On Google PlusVisit Us On Linkedin